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Clinician Run.

Our clinics are all run by licensed and trained healthcare professionals whose passion is making a difference in your life.

Clinician Led.

By focusing on professionalism and friendliness, we empower our clinics to provide you the very best care.

Patient Focused.

We’re more than a clinic. We know our patients. We learn your unique needs. And we provide the care you need to live your healthiest life.

read Our Reviews

22:17 12 Jul 24
Great experience! 10/5 😜 Seriously, great experience though! Everyone was super nice, clean, wait time was not long at all. Dr. Jessica explained everything very well while going over results and straight to the point. Looking forward to treatment. Oh…parking was a breeze also. In and out in 25-30 minutes.
Christine LundChristine Lund
16:24 02 Jul 24
Highly recommend this place to get your hormones checked. I worked with Rachel and she made me feel so good telling me hormonal numbers.
Thor’s GrootThor’s Groot
15:33 25 Jun 24
Optimize U has been nothing but amazing. The results from the treatments have truly met all of my desired wish and wants. The staff from the front end receptionist to the medical staff have been TOP NOTCH! Every time I've called for any question big or small i am immediately greeted with a friendly voice that takes time to listen to my question. All medical appointments have been on point and very helpful. The medical staff take the time to listen while speaking with them without any distractions. If i could recommend this place i would 1,000 times again.
15:28 18 Jun 24
I am in the beginning stages of my TRT treatment. Optimize U has been extremely friendly throughout the process. They answered all my questions and explained all the information in a very understanding way. I would highly recommend anyone who wants to know if TRT is right for them, go to Optimize U
John MillerJohn Miller
03:12 04 Jun 24
Great service and feeling great after a year!
Cortney EthertonCortney Etherton
20:55 09 May 24
Dylan, Rachel and the staff are amazing. Very friendly, knowledgeable and keep up on the most recent technology and treatments. Highly recommend!
Meghan McpeekMeghan Mcpeek
15:18 03 May 24
Friendly professional atmosphere. I’m looking forward to using Optimize for my health needs!
Savannah EvansSavannah Evans
19:43 24 Apr 24
Carmen JamisonCarmen Jamison
18:47 08 Apr 24
Jessica is amazing and easy to talk to. She helped me decide best treatment for me and answered all my questions. Her staff is also amazing. I would highly recommend them.
Danielle McHattonDanielle McHatton
19:11 05 Apr 24
Austin BAustin B
18:01 05 Apr 24
mitch fuzymitch fuzy
18:29 04 Apr 24
Fantastic staff, excellent facilities, and awesome results.
Haley JacksonHaley Jackson
17:34 04 Apr 24
Best pricing for blood work. The staff is very friendly and extremely knowledgeable especially for all my pre and post prep needs! Highly recommend.
Yvonne GemmerYvonne Gemmer
14:53 01 Apr 24
Amy DavisAmy Davis
17:33 05 Mar 24
I have always had a great experience when I visit Optimize U. The staff is top notch! If you’re thinking about going - go! I have never felt better.
Megan wardMegan ward
13:53 05 Mar 24
Great staff all the way around. Coming to a clinic with all sorts of emotions and leaving feeling more confident and hopeful is more than I could ever have hoped for. Thankful for this clinic!
Randall007 SRandall007 S
17:25 01 Mar 24
Dylan MartinDylan Martin
20:39 27 Feb 24
I’m a returning customer very happy to work with this team. Dr. Jessica is knowledgeable and made me feel like she would take the time to really listen to me. Very different than most of my Dr office visits over experienced over the years.
Lane WhelanLane Whelan
17:02 27 Feb 24
Brad BlankenshipBrad Blankenship
17:55 09 Feb 24
Great products and service
Daniel GoldbergDaniel Goldberg
22:04 08 Feb 24
I've been with Optimize U for two and a half years. I have nothing but good things to say about my treatment and results!
Angela ZAngela Z
23:38 06 Feb 24
Aree TAree T
18:28 06 Feb 24
Thank gawd for Optimize U! I have spent yrs knowing something wasn’t right and my gyno refused to check my hormones. I was recommended to Optimize U. They ran my blood panel and guess what, I had no hormones and my thyroid was over worked. Long story short, OU got me taken care of and I feel AMAZING! Thank you!
Julian JohnsJulian Johns
17:59 06 Feb 24
They took my blood and I was in/out in about 10 minutes. I got my labs back in a convenient amount of time and my consultation was one day after that which was awesome! Everyone was great and easy to work with from top to bottom.
Terra SchrembsTerra Schrembs
20:38 22 Jan 24
I LOVE this place!!! Everyone is so friendly and passionate about what they do. I really appreciate that the providers take the time to genuinely listen to my concerns, and I never feel rushed. They offer a fine array of services and customized treatment options! So happy to have found OptimizeU!
outdoors & moreoutdoors & more
20:47 19 Jan 24
Rachel was very professional and polite. She answered all my questions and was very knowledgeable.
Tanya STanya S
23:25 09 Jan 24
The office staff is friendly and I just really like Jessica. She has really helped me with my hot flashes and night sweats. She makes sure that the medication is working and that it’s the correct dose. Everyone should go see her and find out for yourself
Adam ClarkAdam Clark
20:28 05 Jan 24
Ryan HawkinsRyan Hawkins
20:30 21 Dec 23
Autumn ClevelandAutumn Cleveland
22:04 19 Dec 23
I have been coming here for my own health for years, and I have loved they handle each treatment and protocol…so much that I recommend all of myClients and friends to them, because I trust them. They explain everything throughly, are not pressuring, and they are genuine and caring people.
David LaraDavid Lara
13:15 11 Dec 23
Very good and professional team.
Kathy WesleyKathy Wesley
16:40 06 Dec 23
I always love my trips to OptimizeU. The ENTIRE staff is so friendly and knowledgeable. I always feel so good about myself when I leave there. I could sit and chat with them all day.
Yilian VelazquezYilian Velazquez
17:51 05 Dec 23
Jessie ConlinJessie Conlin
19:47 15 Nov 23
I'm super happy with my experience at Optimize U. Everyone there is friendly, attentive, and knowledgeable. Rachel explained everything clearly and answered all my questions. She also provided me with a customized plan that suited my needs and goals. I'm so excited to see the progress I'll be making. Highly recommend!!!
Tara MyersTara Myers
19:55 13 Nov 23
You won’t go wrong coming here!! They’re better at helping you become your best self than anywhere I’ve ever dealt with. The staff is top notch!
Meg PalmerMeg Palmer
19:13 13 Nov 23
Aimee McCaaAimee McCaa
00:29 07 Nov 23
Jessica Matis is just wonderful she listens, reviews labs in details and ask appropriate questions regarding my health. I can’t express how much it means to me that she takes the time to discuss all labs and the hormonal changes that will improve my functioning, sleep and mental well being. Due to this I am transitioning all my hormonal care to OptimizeU.
Andrew BowenAndrew Bowen
20:01 06 Nov 23
So freaking awesome. Wonderful experience and care. They really know what they’re talking about there when it comes to hormones.
lisa byerlylisa byerly
19:49 20 Oct 23
Chadd TChadd T
21:15 16 Oct 23
Brian SparlingBrian Sparling
22:24 14 Oct 23
Very professional wonderful informed staff… very pleased
Daniel DunnDaniel Dunn
18:15 10 Oct 23
Very knowledgeable and straight forward with any and all aspects of TRT and its benefits!!!
shelby eisenbackshelby eisenback
15:30 02 Oct 23
My experience with Optimize U has been nothing short of amazing! The medical staff are extremely professional, and informative, and thoroughly explained everything I needed to know about semaglutide, and why it could assist me with reaching my weight loss goals. I have to give a special shoutout to Rachel, as she has been WONDERFUL to work with, and is extremely responsive to all of my questions I have had throughout this process. I also love that they offer the in-body scan to keep track of my weight loss progression, including fat loss and muscle gain. My husband heard me rave about my experience, and saw the success I am having with semaglutide, and decided to become a customer, too! I will continue to recommend Optimize U to all of my family and friends, and cannot wait to start to use their other amazing services.
Kim JosephKim Joseph
17:09 28 Sep 23
Rachel is the best!!...They offer so many wonderful services. The staff is so welcoming as well.
Jackie ScottsJackie Scotts
18:34 26 Sep 23
Ashley BranhamAshley Branham
00:56 24 Sep 23
I have been so impressed with this clinic and their knowledge about how to optimize my weight loss journey. Rachel is awesome and so relatable! She’s a hype girl for sure ! They seem to a wonderful staff who really cares about the health of their patients!
Maja GuandiqueMaja Guandique
19:39 14 Sep 23
Customer care is unmatched! Dylan is amazing at taking care of patients, is super knowledgeable, and always goes the extra mile!
Aaron KaplanAaron Kaplan
18:08 09 Sep 23
Terra Renee ArlaTerra Renee Arla
19:52 16 Aug 23
I am so impressed with Rachel's knowledge and professionalism. She thoroughly discussed my treatment and ensured my comfort throughout the duration of my visit. I am about 1 month into my Sculpt series, and I am already seeing drastic results on my once stubborn abdominal area. I also want to mention that the entire staff is so friendly and always makes me feel right at home. OptimizeU is truly a one stop shop filled with knowledgable professionals eager to help you reach your goals!
Rachel RayRachel Ray
16:49 20 Jul 23
Love this business and my experience with them! The staff is so helpful to direct you to all options to achieve your goals. Dr Jessica is very knowledgeable about hormones and can help you better understand your lab panel. I’m so thankful I found them!
Marshall MummertMarshall Mummert
20:13 06 Jul 23
Great place, great service. Friendly knowledge staff.
John MillerJohn Miller
21:22 21 Jun 23
So thankful I found Optimize U! The service is far better than any place I have ever been and they are very well educated on any question you may have. Friendly staff and a great environment. Love the fact that I have stepped outside my comfort zone and given Cryotherapy a try. Totally worth it! It’s TWO THUMBS UP from me!
Ashley YoergAshley Yoerg
18:02 21 Jun 23
I can not say enough good things about Optimizeu. The facility is immaculate, but also inviting. The staff is friendly, skilled and professional. The services I have received were performed accurately and efficiently in regards to time. I would highly recommend Optimizeu to any friend or family member.
Derek GrondaDerek Gronda
23:03 20 Jun 23
After searching several places I came across optimize and haven’t looked back. Friendly professional and very knowledgeable staff. At 42 I’m thriving and crushing at life again, in all aspects. I’ve recommended several people by word of mouth including those closest to me, now I’m recommending you. If you’re reading this, chances are you’re not feeling yourself these days, not the best you can/could be, do yourself a favor and invest in yourself, your mental and physical health. Be the best you can be, thank me later!
Mary MeyerMary Meyer
20:54 06 Jun 23
I’ve been to Rachel several times for microneedling and Botox. She takes great care of me. She guides me to pick the treatments that will best meet my skin care goals. She takes a lot of time to make me feel comfortable. She’s very diligent about properly numbing me before the treatments that require it. She also keeps an open line of communication after treatments and can easily be reached if I have any follow-up questions or concerns. I cannot recommend her services enough. The treatment rooms are very clean, and the design is awesome. I tell everyone that I know that they need to go see her for any of their hormone or skin concerns.
Chelsie SkillmanChelsie Skillman
03:41 31 May 23
I really have to have a lot of trust in the people taking care of me, and I definitely found that in Rachel at optimize U. I would send any of my family to her and know that they would be in great hands. I went to optimize U to get labs and an IV.The IV menu is super fun and I love all the options but Rachel was great & helped me choose based off of my overall goal for therapy. While my IV was going I got to sit in the most comfortable massage chair and watch TV, while Rachel checked on me multiple times. It was the most relaxed I’ve been in a while. Everything is very clean and it has the cutest decorations! I’m looking forward to monthly treatments to boost my health and wellness! I even had follow up for a semaglutide consult.Just all around good vibes, you can’t go wrong with anything here.
Juliana VJuliana V
20:30 30 May 23
Optimize U is this magical place where you become the best version of yourself! My entire life, I had always struggled to lose weight and get in shape - I tried just about every exercise/ dieting program and then reached a point where I just accepted that this is the way I would always look. Jessica and Rachel, along with the entire Optimize U team, were able to meet me where I was at and help me gain control of my life. The Semaglutide injections helped me with my weight loss journey and allowed me to finally feel confident in my own skin for the first time ever - And I’m very excited to try Mounjaro next!Since having found out about Optimize U, and all of the services they provide, I have also become a huge fan of micro-needling and Dysport! After having these treatments, my face and skin look healthier and more vibrant than ever. Especially going into the summer months, it makes such a difference not feeling like you need to wear makeup to cover up all of those imperfections and wrinkles.I also have struggled with hair thinning which, as a woman, has made me feel very self conscious. Rachel introduced me to Nutrafol and it has made SUCH a difference! I have been taking Nutrafol along with Reds & Greens since December and my hair dresser has been amazed by all my new hair growth.Finally, I can’t say enough about the staff at Optimize U. They always make me feel so comfortable and validated in my expectations of what I am looking to achieve for myself. Jessica and Rachel are extremely knowledgeable about all of their products and services and I am so grateful for them!

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1401 Veterans Parkway Suite 700 Clarksville, IN 47129

Contact Us

(812) 913-5002

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No Practitioner is available in this location

Jessica Matis DNP/ACNP-AG

Paul Weinberger, DO

Rachel Killen, NP

Jessica Matis DNP/ACNP-AG


I received my Doctorate in Nursing as an Adult Care Nurse Practitioner from the University of Kentucky, in 2015. Since then, I have specialized in Adult Care treating a wide array of illnesses and diseases. Throughout my career I have found my greatest passion in treating hormonal imbalances in both men and women. My husband and I have both experienced the frustration of going to our Primary care provider with symptoms and being told “our labs are normal” and “we are healthy”, even though we did not feel good. We both feel passionate about Optimize U and what it has to offer the community in and around Louisville. I make it a priority to treat patients like family and base care on symptoms and not just numbers alone.

Paul Weinberger, DO


Dr. Paul Weinberger grew up in West Virginia. After attending both the University of Kentucky and Marshall University, he attended medical school in Erie, PA. There he became a board-certified emergency medicine doctor (ABEM), having completed his residency at Thomas Jefferson University Hospital in Philadelphia, PA.

His passions include his love of travel, shopping for deals, eating unique foods from all over the world, and exercise.

“I believe hormone therapy is the foundation for optimizing quality of life.”

Rachel Killen