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Clinician Run.
Our clinics are all run by licensed and trained healthcare professionals whose passion is making a difference in your life.

Clinician Led.
By focusing on professionalism and friendliness, we empower our clinics to provide you the very best care.

Patient Focused.
We’re more than a clinic. We know our patients. We learn your unique needs. And we provide the care you need to live your healthiest life.
read Our Reviews

Friendly and professional staff, Jewells at the front desk was top notch! Could t have asked for a better experience!
I am so excited to be on this journey taking back my health! Thank you Jessica for making me feel heard and understood! OptimizeU is a no brainer! Don’t wait any longer, go see them today!
I couldn’t speak higher of OptimizeU! Everyone is so kind, professional and unbelievably knowledgeable! I appreciate that they truly take the time to listen to my concerns and create a completely customized treatment plan for me! I’m loving the results!!!
Jessica Matise and her staff provided excellent care. She was always available to answer my questions, my health and wellbeing was her primary concern.
I absolutely love OptimizeU Louisville. They have helped me turn my health around and I feel so much better. It’s only been a year now and I wish I had started this journey earlier. Thank you Rachel and Dylan and all the other amazing staff! Keep up the great work! Love you all! ❤️
I love their sauna and cold plunge. It's definitely an extremely intense process, but it helps tremendously with pain relief.
Extremely kind & helpful staff. Very pleasant experience, I won't be going anywhere else!
Such a great experience! Dr. Jessica Matts has helped me understand and educate me about my POCS. When I first went to Optimize U it was just to check my horomones for body building purposes but I got so much more.For 4 years I thought something was seriously wrong with my menstrual cycle between the extremely short and heavy periods to mood swings so bad I thought I was possessed!! I seen several doctors who told me everything was fine.. it’s just my horomones.. “I was a lucky one to only have a 2 day period”..Fast forward to 4 YEARS LATER.. the wonderful Dr. Matt’s gave me so much insight and help me understand I have POCS! This has been life changing for me!
My husband and I both started here for various different services and love it. The facility and staff are all top notch!
I have been going to Optimize U for over a year now. I can't say enough great things about them. Rachel is who I deal with the most and she is absolutely the best. She always answers all my questions and always has my best interest in mind. I feel so lucky to have found Optimize U. I have lost about 25-30 pounds, and they have put me on hormone therapy which has made all the difference. If you are having any issues I highly recommend. From weight loss to hormones, I am so thankful. I can't imagine going anywhere else. They are all so friendly and so helpful. Call today you will not be sorry!!
I have had a very positive experience with Optimize U. Rachel and Dylan have helped me navigate my struggles through perimenopause. Rachel is always responsive and thorough with her feedback. I have already referred 2 of my friends who were not having a good experience with their providers. I highly recommend Optimize U. So glad I found them!
Amazing staff and service! Rachel and Dylan are incredibly professional, knowledgeable, and responsive. Whenever I have a question, I can get an immediate response. The hormone therapy has been a game changer for me. I HIGHLY recommend Optimize U!
Best place to go to hands down. No sales gimmick, they give you the best advice for you and not just what is good for business. I have had questions outside of my office visits and they are quick to respond. I don’t know why you would go anywhere else.
Going to Optimize U has helped my mind and body be the best it can be. They will help you to feel your true you than anywhere else. Call them, you wont regret it
I was taken care of and given an extensive conversation and wealth of knowledge given my hormonal/weight loss needs. Haven't recieved medicine yet, but the practitioner and her nurses are wonderful to speak with. Say hi to Biggie if ya stop by!
Great experience! 10/5 😜 Seriously, great experience though! Everyone was super nice, clean, wait time was not long at all. Dr. Jessica explained everything very well while going over results and straight to the point. Looking forward to treatment. Oh…parking was a breeze also. In and out in 25-30 minutes.
Highly recommend this place to get your hormones checked. I worked with Rachel and she made me feel so good telling me hormonal numbers.
Optimize U has been nothing but amazing. The results from the treatments have truly met all of my desired wish and wants. The staff from the front end receptionist to the medical staff have been TOP NOTCH! Every time I've called for any question big or small i am immediately greeted with a friendly voice that takes time to listen to my question. All medical appointments have been on point and very helpful. The medical staff take the time to listen while speaking with them without any distractions. If i could recommend this place i would 1,000 times again.
I am in the beginning stages of my TRT treatment. Optimize U has been extremely friendly throughout the process. They answered all my questions and explained all the information in a very understanding way. I would highly recommend anyone who wants to know if TRT is right for them, go to Optimize U
Dylan, Rachel and the staff are amazing. Very friendly, knowledgeable and keep up on the most recent technology and treatments. Highly recommend!
Friendly professional atmosphere. I’m looking forward to using Optimize for my health needs!
Jessica is amazing and easy to talk to. She helped me decide best treatment for me and answered all my questions. Her staff is also amazing. I would highly recommend them.
Best pricing for blood work. The staff is very friendly and extremely knowledgeable especially for all my pre and post prep needs! Highly recommend.
I have always had a great experience when I visit Optimize U. The staff is top notch! If you’re thinking about going - go! I have never felt better.
Great staff all the way around. Coming to a clinic with all sorts of emotions and leaving feeling more confident and hopeful is more than I could ever have hoped for. Thankful for this clinic!
I’m a returning customer very happy to work with this team. Dr. Jessica is knowledgeable and made me feel like she would take the time to really listen to me. Very different than most of my Dr office visits over experienced over the years.
I've been with Optimize U for two and a half years. I have nothing but good things to say about my treatment and results!
Today, I went into Optimize U for skin concerns. Rachel and I talked about my concerns and what I wanted to achieve. Going over some options and what she suggested we came to an agreement what the game plans is. I can’t wait to get started! Thanks Rachel and staff at Optimize U for your professionalism and listening to my concerns. Love you all, & Biggie!
They took my blood and I was in/out in about 10 minutes. I got my labs back in a convenient amount of time and my consultation was one day after that which was awesome! Everyone was great and easy to work with from top to bottom.
I LOVE this place!!! Everyone is so friendly and passionate about what they do. I really appreciate that the providers take the time to genuinely listen to my concerns, and I never feel rushed. They offer a fine array of services and customized treatment options! So happy to have found OptimizeU!
Rachel was very professional and polite. She answered all my questions and was very knowledgeable.
The office staff is friendly and I just really like Jessica. She has really helped me with my hot flashes and night sweats. She makes sure that the medication is working and that it’s the correct dose. Everyone should go see her and find out for yourself
I have been coming here for my own health for years, and I have loved they handle each treatment and protocol…so much that I recommend all of myClients and friends to them, because I trust them. They explain everything throughly, are not pressuring, and they are genuine and caring people.
I always love my trips to OptimizeU. The ENTIRE staff is so friendly and knowledgeable. I always feel so good about myself when I leave there. I could sit and chat with them all day.
I'm super happy with my experience at Optimize U. Everyone there is friendly, attentive, and knowledgeable. Rachel explained everything clearly and answered all my questions. She also provided me with a customized plan that suited my needs and goals. I'm so excited to see the progress I'll be making. Highly recommend!!!
You won’t go wrong coming here!! They’re better at helping you become your best self than anywhere I’ve ever dealt with. The staff is top notch!
Jessica Matis is just wonderful she listens, reviews labs in details and ask appropriate questions regarding my health. I can’t express how much it means to me that she takes the time to discuss all labs and the hormonal changes that will improve my functioning, sleep and mental well being. Due to this I am transitioning all my hormonal care to OptimizeU.
So freaking awesome. Wonderful experience and care. They really know what they’re talking about there when it comes to hormones.
Very knowledgeable and straight forward with any and all aspects of TRT and its benefits!!!
My experience with Optimize U has been nothing short of amazing! The medical staff are extremely professional, and informative, and thoroughly explained everything I needed to know about semaglutide, and why it could assist me with reaching my weight loss goals. I have to give a special shoutout to Rachel, as she has been WONDERFUL to work with, and is extremely responsive to all of my questions I have had throughout this process. I also love that they offer the in-body scan to keep track of my weight loss progression, including fat loss and muscle gain. My husband heard me rave about my experience, and saw the success I am having with semaglutide, and decided to become a customer, too! I will continue to recommend Optimize U to all of my family and friends, and cannot wait to start to use their other amazing services.
Rachel is the best!!...They offer so many wonderful services. The staff is so welcoming as well.
I have been so impressed with this clinic and their knowledge about how to optimize my weight loss journey. Rachel is awesome and so relatable! She’s a hype girl for sure ! They seem to a wonderful staff who really cares about the health of their patients!
Customer care is unmatched! Dylan is amazing at taking care of patients, is super knowledgeable, and always goes the extra mile!
I am so impressed with Rachel's knowledge and professionalism. She thoroughly discussed my treatment and ensured my comfort throughout the duration of my visit. I am about 1 month into my Sculpt series, and I am already seeing drastic results on my once stubborn abdominal area. I also want to mention that the entire staff is so friendly and always makes me feel right at home. OptimizeU is truly a one stop shop filled with knowledgable professionals eager to help you reach your goals!
Love this business and my experience with them! The staff is so helpful to direct you to all options to achieve your goals. Dr Jessica is very knowledgeable about hormones and can help you better understand your lab panel. I’m so thankful I found them!
So thankful I found Optimize U! The service is far better than any place I have ever been and they are very well educated on any question you may have. Friendly staff and a great environment. Love the fact that I have stepped outside my comfort zone and given Cryotherapy a try. Totally worth it! It’s TWO THUMBS UP from me!
I can not say enough good things about Optimizeu. The facility is immaculate, but also inviting. The staff is friendly, skilled and professional. The services I have received were performed accurately and efficiently in regards to time. I would highly recommend Optimizeu to any friend or family member.
After searching several places I came across optimize and haven’t looked back. Friendly professional and very knowledgeable staff. At 42 I’m thriving and crushing at life again, in all aspects. I’ve recommended several people by word of mouth including those closest to me, now I’m recommending you. If you’re reading this, chances are you’re not feeling yourself these days, not the best you can/could be, do yourself a favor and invest in yourself, your mental and physical health. Be the best you can be, thank me later!
I’ve been to Rachel several times for microneedling and Botox. She takes great care of me. She guides me to pick the treatments that will best meet my skin care goals. She takes a lot of time to make me feel comfortable. She’s very diligent about properly numbing me before the treatments that require it. She also keeps an open line of communication after treatments and can easily be reached if I have any follow-up questions or concerns. I cannot recommend her services enough. The treatment rooms are very clean, and the design is awesome. I tell everyone that I know that they need to go see her for any of their hormone or skin concerns.
I really have to have a lot of trust in the people taking care of me, and I definitely found that in Rachel at optimize U. I would send any of my family to her and know that they would be in great hands. I went to optimize U to get labs and an IV.The IV menu is super fun and I love all the options but Rachel was great & helped me choose based off of my overall goal for therapy. While my IV was going I got to sit in the most comfortable massage chair and watch TV, while Rachel checked on me multiple times. It was the most relaxed I’ve been in a while. Everything is very clean and it has the cutest decorations! I’m looking forward to monthly treatments to boost my health and wellness! I even had follow up for a semaglutide consult.Just all around good vibes, you can’t go wrong with anything here.
Optimize U is this magical place where you become the best version of yourself! My entire life, I had always struggled to lose weight and get in shape - I tried just about every exercise/ dieting program and then reached a point where I just accepted that this is the way I would always look. Jessica and Rachel, along with the entire Optimize U team, were able to meet me where I was at and help me gain control of my life. The Semaglutide injections helped me with my weight loss journey and allowed me to finally feel confident in my own skin for the first time ever - And I’m very excited to try Mounjaro next!Since having found out about Optimize U, and all of the services they provide, I have also become a huge fan of micro-needling and Dysport! After having these treatments, my face and skin look healthier and more vibrant than ever. Especially going into the summer months, it makes such a difference not feeling like you need to wear makeup to cover up all of those imperfections and wrinkles.I also have struggled with hair thinning which, as a woman, has made me feel very self conscious. Rachel introduced me to Nutrafol and it has made SUCH a difference! I have been taking Nutrafol along with Reds & Greens since December and my hair dresser has been amazed by all my new hair growth.Finally, I can’t say enough about the staff at Optimize U. They always make me feel so comfortable and validated in my expectations of what I am looking to achieve for myself. Jessica and Rachel are extremely knowledgeable about all of their products and services and I am so grateful for them!
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Practitioners
No Practitioner is available in this location

Jessica Matis DNP/ACNP-AG

Paul Weinberger, DO
