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Optimize U Evansville, Indiana

How We Can Help

Clinician Run.

Our clinics are all run by licensed and trained healthcare professionals whose passion is making a difference in your life.

Clinician Led.

By focusing on professionalism and friendliness, we empower our clinics to provide you the very best care.

Patient Focused.

We’re more than a clinic. We know our patients. We learn your unique needs. And we provide the care you need to live your healthiest life.

read Our Reviews

Mark BurkeMark Burke
21:04 07 Jun 24
Staff is very knowledgeable, courteous and helpful!
Jennifer McBrideJennifer McBride
15:09 07 Jun 24
Had an amazing consultation and excited to get started.
B ArchieB Archie
21:16 22 May 24
Just started working with them. They have been a pleasure to work with and are very informative of the process.
Gavin TenbargeGavin Tenbarge
20:33 27 Mar 24
Jason BoyleJason Boyle
21:59 21 Mar 24
I walked into Optimize U a few months ago because I felt like I had no control over my own physical health. Now I feel the exact opposite. My only regret is not going sooner
Jesse NixonJesse Nixon
22:45 14 Mar 24
Jessica was very awesome, she listens to everything you have to say. I ran my appt. Over 30 mins and she never rushed me once. I highly recommend this place, the staff is very good to work with.
Jason FeightnerJason Feightner
22:26 04 Mar 24
Very informative and thorough in answering all my questions.
Irene FerrellIrene Ferrell
18:42 20 Feb 24
Paige and Jessica did a wonderful job explaining what the process could be and options to have better health experience 😀
Beau CunninghamBeau Cunningham
15:48 11 Feb 24
Excellent people to work with.
Hailey HobdyHailey Hobdy
22:51 15 Jan 24
Jessica and Paige are the absolute best!
Sean SagerSean Sager
18:10 02 Jan 24
Very polite and pleasant to work with! Communication is very clear with them and treatment is explained to ensure the patient understands what’s going on.
Matt AmbroseMatt Ambrose
17:50 28 Dec 23
The time the staff takes to listen and develop a plan for your heath needs is years ahead of anyone else in our area! What they offer is something you would find in Arizona or south Florida, they truly want to keep you healthy and youthful!
Scott SmithScott Smith
22:57 20 Dec 23
Friendly and always ready to answer any question.
Felix QuinonesFelix Quinones
23:22 19 Dec 23
Very friendly staff very honest was able to help me with my situation. I Highly recommend them
Looj PoojLooj Pooj
21:49 18 Dec 23
Jessica seemed very knowledgeable and thorough with pre lab work and treatment Would recommend stopping by and checking it out.
Debbie HowardDebbie Howard
21:48 01 Nov 23
Very knowledgeable and professional!
Ron KnirsRon Knirs
17:14 05 Oct 23
I love all the services offered by Optimize U. Lost 25 pounds in the last 3 months with their help.The staff st Optimize U are very knowledgeable and eager to help
Kevin RutledgeKevin Rutledge
17:38 11 Sep 23
Can’t say enough good stuff about this place. They got me feeling a ton better in just a matter of months. Super sweet people (Paige and Jessica) and a great addition to the guntry club.
Alyssa SheltonAlyssa Shelton
19:27 03 Sep 23
The staff is one-of- a-kind! Super friendly and friendly. 10/10. Highly recommend going here for all things hormonal, muscle recovery, and athlete related!!
Dedrick CosbyDedrick Cosby
16:51 30 Aug 23
This place is awesome. It’s a one stop shop. The fact that I can get hormone therapy, cold plunge and infrared, sauna sauna with red light therapy all in one place is unheard of. Definitely has been a game cheater for me.
Danny BlandfordDanny Blandford
16:23 30 Aug 23
Do yourself a favor... save time & frustration trying to figure out what supplements you may or may not need in your fitness/wellness journey. Getting the appropriate labs that will indicate your personal needs along with in depth consultation from the amazing staff has benefited me greatly!
The Incredible FulkThe Incredible Fulk
15:41 30 Aug 23
Incredible experience with staff, lab process, and receiving my peptides/supplies! Jessica and Derek are amazing medical professional practitioners that treat my lab results as well as listened to my self assessed-symptoms! I’ve immediately felt the energy, strength, and confidence that I lacked in my day to day! Paige is what brings it all together and her client hospitality skills are second to no-ones! Always responsive to my questions and unique time availability getting in to Sauna and Polar Plunge in their state of the art equipment! I absolutely love this place and the access to its health benefits!!
Carla WiseCarla Wise
18:48 29 Aug 23
Nothing but positive energy at this place. Paige at the front desk greets you with a smile as soon as you walk in. Jessica and Derek are very educated nurse practitioners that will get you on the right path customized to you. Whether it’s weight loss, hormone replacement or work out recovery they are the best at providing personalized treatment. I am finally losing weight thanks to my provider, Jessica, and believe me, I’ve tried everything! Check out Optimize U in Evansville IN. You won’t be disappointed.
Nikki BlandfordNikki Blandford
15:10 26 Aug 23
A must try for anyone wanting to achieve optimal health through in-depth labs & personal consultation! I had been diagnosed by a medical provider with a hormonal condition without extensive labs & fortunately I did not start on any type of hormone regiment, but sought the expertise of the OptimizeU staff. The previous diagnosis was incorrect & I was advised to start natural supplements to meet my specific needs… so grateful for the services offered here by the amazing staff!
Megan ShowalterMegan Showalter
19:12 25 Aug 23
Had such a great experience! Such a clean, nice place and the staff was AMAZING. I will recommend Optimize-U to anyone wanting to improve their health or even just feel better!

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4209 US Hwy 41, Suite 24 Evansville, IN 47714

Contact Us


Refills Text Line :

TEXT (930) 205-8592 TO REFILL MY MEDS

Hours :

Monday -
9 a.m. - 5 p.m. regular clinic hours
5 p.m. - 7 p.m. by appointment only

Tuesday -
9 a.m. - 5 p.m. regular clinic hours
5 p.m. - 7 p.m. by appointment only

Wednesday -
9 a.m. - 5 p.m. regular clinic hours
5 p.m. - 7 p.m. by appointment only

Thursday -
9 a.m. - 5 p.m. regular clinic hours
5 p.m. - 7 p.m. by appointment only

Friday -
9 a.m. - 5 p.m. regular clinic hours

Saturday -
7 a.m. - 1 p.m. lab draws & recovery services only



Derek Shelton, DNP

Jessica Blandford, NP

Robert Howard, MD

Derek Shelton


Jessica Blandford


Robert Howard, MD


As a Vanderbilt graduate, Dr. Howard studied at Harvard and conducted research at Massachusetts General Hospital. Upon earning his degree from the University of Kentucky College of Medicine, he completed his residency and fellowship training at UK and Vanderbilt.

Dr. Howard is interested in the mental health benefits of hormone optimization. With a background in psychiatry and addiction medicine, he provides a unique perspective on hormone optimization, which he sees as a necessary foundation for one’s health and vitality. Dr. Howard’s journey with hormone optimization has been nothing short of transformative. He is enthusiastic to share his knowledge and experience with his patients, helping them to look and feel their best.

Dr. Howard is licensed to practice medicine in Kentucky, Tennessee, and Ohio. He provides aesthetic services such as Botox in addition to hormone optimization.